Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes.

AZT-P-ddI is an antiviral heterodimer composed of one molecule of 3'-azido-3'-deoxythymidine (AZT) and one molecule of 2',3'-dideoxyinosine (ddI) linked through their 5' positions by a phosphate bond. The metabolic fate of the dimer was studied with isolated rat, monkey, and human hepatocytes and wa...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Pan-Zhou, X R, Cretton-Scott, E, Zhou, X J, Xie, M Y, Rahmani, R, Schinazi, R F, Duchin, K, Sommadossi, J P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164152/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371357/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.11.2502
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