Inhibitory activities of quinolones against DNA gyrase and topoisomerase IV purified from Staphylococcus aureus.

In order to clarify the mechanism of action of quinolones against Staphylococcus aureus, GrlA and GrlB proteins of topoisomerase IV encoded by genes with or without mutations were purified separately as fusion proteins with maltose-binding protein in Escherichia coli. The reconstituted enzymes showe...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Tanaka, M, Onodera, Y, Uchida, Y, Sato, K, Hayakawa, I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371334/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.11.2362
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