Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.

The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The echinocandins are potent inhibitors of 1,3-beta-D-glucan synthase. Two models of disseminated candidiasis wer...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, Balkovec, J M, Bouffard, A F, Dropinski, J F, Rosen, H, Kropp, H, Bartizal, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164124/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371329/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.11.2333
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