In vivo antiviral activity and pharmacokinetics of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in woodchuck hepatitis virus-infected woodchucks.

The (-) enantiomer of cis-5-fluoro-1l-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine [(-)-FTC)], a substituted oxathiolane compound with anti-hepatitis B virus activity in vitro, was assessed for its efficacy in woodchucks with naturally acquired woodchuck hepatitis virus (WHV) infection. Pharmacok...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Cullen, J M, Smith, S L, Davis, M G, Dunn, S E, Botteron, C, Cecchi, A, Linsey, D, Linzey, D, Frick, L, Paff, M T, Goulding, A, Biron, K
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164073/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9333028/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.10.2076
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