Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations.

Amino acid changes that influence activity and resistance to beta-lactams and beta-lactamase inhibitors were explored by constructing the Gly238Ser and Met69Ile-Gly238Ser mutants of the OHIO-1 beta-lactamase, a class A enzyme of the SHV family. The Km values of cefotaxime and ceftazidime for OHIO-1...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Bonomo, R A, Knox, J R, Rudin, S D, Shlaes, D M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164040/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9303389/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.9.1940
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