Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to D,L-alpha-difluoromethylornithine.

Ornithine decarboxylase (ODC), the target enzyme of D,L-alpha-difluoromethylornithine (DFMO), was investigated in four DFMO-tolerant Trypanosoma brucei rhodesiense isolates from East Africa and two DFMO-susceptible T. b. gambiense isolates from West Africa. Neither drug uptake nor inhibition of ODC...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Iten, M, Mett, H, Evans, A, Enyaru, J C, Brun, R, Kaminsky, R
Format: Artigo
Langue:Inglês
Publié: 1997
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC164036/
https://ncbi.nlm.nih.gov/pubmed/9303385
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