Alterations in ornithine decarboxylase characteristics account for tolerance of Trypanosoma brucei rhodesiense to D,L-alpha-difluoromethylornithine.

Ornithine decarboxylase (ODC), the target enzyme of D,L-alpha-difluoromethylornithine (DFMO), was investigated in four DFMO-tolerant Trypanosoma brucei rhodesiense isolates from East Africa and two DFMO-susceptible T. b. gambiense isolates from West Africa. Neither drug uptake nor inhibition of ODC...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Iten, M, Mett, H, Evans, A, Enyaru, J C, Brun, R, Kaminsky, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164036/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9303385/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.9.1922
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