Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B.

Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage-like J774.16 cells in a dose-dependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically....

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Mozaffarian, N, Berman, J W, Casadevall, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9257771/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.8.1825
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