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Ethambutol resistance in Mycobacterium tuberculosis: critical role of embB mutations.

Ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB], is a first-line drug used to treat tuberculosis. To gain insight into the molecular basis of EMB resistance, we characterized the 10-kb embCAB locus in 16 EMB-resistant and 3 EMB-susceptible genetically distinct Mycobacterium tuberculosis...

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Published in:Antimicrob Agents Chemother
Main Authors: Sreevatsan, S, Stockbauer, K E, Pan, X, Kreiswirth, B N, Moghazeh, S L, Jacobs, W R, Telenti, A, Musser, J M
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1997
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163984/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9257740/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.8.1677
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