Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development.

We have isolated and sequenced a novel 11-kDa virucidal protein, named cyanovirin-N (CV-N), from cultures of the cyanobacterium (blue-green alga) Nostoc ellipsosporum. We also have produced CV-N recombinantly by expression of a corresponding DNA sequence in Escherichia coli. Low nanomolar concentrat...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Boyd, M R, Gustafson, K R, McMahon, J B, Shoemaker, R H, O'Keefe, B R, Mori, T, Gulakowski, R J, Wu, L, Rivera, M I, Laurencot, C M, Currens, M J, Cardellina, J H, Buckheit, R W, Nara, P L, Pannell, L K, Sowder, R C, Henderson, L E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163952/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9210678/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.7.1521
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