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The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans.
Azole resistance in the pathogenic yeast Candida albicans is an emerging problem in the human immunodeficiency virus (HIV)-infected population. The target enzyme of the azole drugs is lanosterol 14alpha demethylase (Erg16p), a cytochrome P-450 enzyme in the biosynthetic pathway of ergosterol. Bioche...
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
1997
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC163945/ https://ncbi.nlm.nih.gov/pubmed/9210671 |
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