Pharmacokinetics of zidovudine after rectal administration in human immunodeficiency virus-infected patients.

We evaluated the pharmacokinetics of rectally administered zidovudine (ZDV) in 10 human immunodeficiency virus-infected adults. After rectal administration of an aqueous ZDV solution (250 mg of ZDV), mean peak ZDV levels were 1.3 +/- 0.7 micromol/liter (mean +/- standard deviation) versus 5.0 +/- 2....

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Wintergerst, U, Rolinski, B, Bogner, J R, Notheis, G, Goebel, F D, Roscher, A A, Belohradsky, B H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163866/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9145885/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.5.1143
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