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Pharmacokinetics of zidovudine after rectal administration in human immunodeficiency virus-infected patients.

We evaluated the pharmacokinetics of rectally administered zidovudine (ZDV) in 10 human immunodeficiency virus-infected adults. After rectal administration of an aqueous ZDV solution (250 mg of ZDV), mean peak ZDV levels were 1.3 +/- 0.7 micromol/liter (mean +/- standard deviation) versus 5.0 +/- 2....

詳細記述

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Wintergerst, U, Rolinski, B, Bogner, J R, Notheis, G, Goebel, F D, Roscher, A A, Belohradsky, B H
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 1997
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163866/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9145885/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.5.1143
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