Enhanced resistance to Cryptococcus neoformans infection induced by chloroquine in a murine model of meningoencephalitis.

Although the pathogenesis of cerebral cryptococcosis is poorly understood, local immune cells, such as microglia and astrocytes, likely play a critical role in containing infection. Chloroquine (CQ) is a weak base that accumulates within acidic vacuoles and increases their pH. Consequently, proteoly...

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Bibliographic Details
Main Authors: Mazzolla, R, Barluzzi, R, Brozzetti, A, Boelaert, J R, Luna, T, Saleppico, S, Bistoni, F, Blasi, E
Format: Artigo
Language:Inglês
Published: 1997
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC163798/
https://ncbi.nlm.nih.gov/pubmed/9087493
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