Enhanced resistance to Cryptococcus neoformans infection induced by chloroquine in a murine model of meningoencephalitis.

Although the pathogenesis of cerebral cryptococcosis is poorly understood, local immune cells, such as microglia and astrocytes, likely play a critical role in containing infection. Chloroquine (CQ) is a weak base that accumulates within acidic vacuoles and increases their pH. Consequently, proteoly...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Mazzolla, R, Barluzzi, R, Brozzetti, A, Boelaert, J R, Luna, T, Saleppico, S, Bistoni, F, Blasi, E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9087493/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.4.802
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