Development of a physiologically based pharmacokinetic model of trichloroethylene and its metabolites for use in risk assessment.

A physiologically based pharmacokinetic (PBPK) model was developed that provides a comprehensive description of the kinetics of trichloroethylene (TCE) and its metabolites, trichloroethanol (TCOH), trichloroacetic acid (TCA), and dichloroacetic acid (DCA), in the mouse, rat, and human for both oral...

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Bibliographic Details
Main Authors: Clewell, H J, Gentry, P R, Covington, T R, Gearhart, J M
Format: Artigo
Language:Inglês
Published: 2000
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637761/
https://ncbi.nlm.nih.gov/pubmed/10807559
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