Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737.

The S,S enantiomer of the bisquinoline trans-N1,N2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine, Ro 47-7737, is significantly more potent against chloroquine-resistant Plasmodium falciparum than the R,R enantiomer and the previously described racemate. Both the enantiomers and the racemate are...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Ridley, R G, Matile, H, Jaquet, C, Dorn, A, Hofheinz, W, Leupin, W, Masciadri, R, Theil, F P, Richter, W F, Girometta, M A, Guenzi, A, Urwyler, H, Gocke, E, Potthast, J M, Csato, M, Thomas, A, Peters, W
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1997
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163771/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9056013/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.3.677
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Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737.

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