Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737.

The S,S enantiomer of the bisquinoline trans-N1,N2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine, Ro 47-7737, is significantly more potent against chloroquine-resistant Plasmodium falciparum than the R,R enantiomer and the previously described racemate. Both the enantiomers and the racemate are...

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Detalhes bibliográficos
Main Authors: Ridley, R G, Matile, H, Jaquet, C, Dorn, A, Hofheinz, W, Leupin, W, Masciadri, R, Theil, F P, Richter, W F, Girometta, M A, Guenzi, A, Urwyler, H, Gocke, E, Potthast, J M, Csato, M, Thomas, A, Peters, W
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC163771/
https://ncbi.nlm.nih.gov/pubmed/9056013
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