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Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term po...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Maher, Pamela, Akaishi, Tatsuhiro, Abe, Kazuho
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637622/
https://ncbi.nlm.nih.gov/pubmed/17050681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607822103
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