Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia

Mixl1, the sole murine homologue of the Xenopus Mix/Bix family of homeobox transcription factors, is essential for the patterning of axial mesendodermal structures during early embryogenesis. Gene targeting and overexpression studies have implicated Mixl1 as a regulator of hematopoiesis arising in d...

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Detalhes bibliográficos
Main Authors: Glaser, Stefan, Metcalf, Donald, Wu, Li, Hart, Adam H., DiRago, Ladina, Mifsud, Sandra, D'Amico, Angela, Dagger, Samantha, Campo, Chiara, Chan, Angela C., Izon, David J., Robb, Lorraine
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637604/
https://ncbi.nlm.nih.gov/pubmed/17060613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607776103
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