Membrane-dependent oligomeric structure and pore formation of a β-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR

We used solid-state NMR spectroscopy to investigate the oligomeric structure and insertion of protegrin-1 (PG-1), a β-hairpin antimicrobial peptide, in lipid bilayers that mimic either the bacterial inner membrane [palmitoyloleoylphosphatidyl ethanolamine and palmitoyloleoylphosphatidylglycerol (POP...

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Main Authors: Mani, Rajeswari, Cady, Sarah D., Tang, Ming, Waring, Alan J., Lehrer, Robert I., Hong, Mei
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1637567/
https://ncbi.nlm.nih.gov/pubmed/17060626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605079103
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