AML1/RUNX1 Phosphorylation by Cyclin-Dependent Kinases Regulates the Degradation of AML1/RUNX1 by the Anaphase-Promoting Complex

AML1 (RUNX1) regulates hematopoiesis, angiogenesis, muscle function, and neurogenesis. Previous studies have shown that phosphorylation of AML1, particularly at serines 276 and 303, affects its transcriptional activation. Here, we report that phosphorylation of AML1 serines 276 and 303 can be blocke...

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Autores principales: Biggs, Joseph R., Peterson, Luke F., Zhang, Youhong, Kraft, Andrew S., Zhang, Dong-Er
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636878/
https://ncbi.nlm.nih.gov/pubmed/17015473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00597-06
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