Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV.

The locus nfxD, which contributes to high-level quinolone resistance in Escherichia coli KF111b (gyrAr nfxB nfxD), is only expressed in the presence of a gyrA mutation, and maps to the region of the parC and parE genes, was outcrossed into strain KF130, creating strain DH161 (gyrAr nfxD). DNA sequen...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Breines, D M, Ouabdesselam, S, Ng, E Y, Tankovic, J, Shah, S, Soussy, C J, Hooper, D C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163680/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8980775/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.41.1.175
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