Only Akt1 Is Required for Proliferation, while Akt2 Promotes Cell Cycle Exit through p21 Binding

Protein kinase B (PKB/Akt) is an important modulator of insulin signaling, cell proliferation, and survival. Using small interfering RNA duplexes in nontransformed mammalian cells, we show that only Akt1 is essential for cell proliferation, while Akt2 promotes cell cycle exit. Silencing Akt1 resulte...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Héron-Milhavet, Lisa, Franckhauser, Celine, Rana, Vanessa, Berthenet, Cyril, Fisher, Daniel, Hemmings, Brian A., Fernandez, Anne, Lamb, Ned J. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636765/
https://ncbi.nlm.nih.gov/pubmed/16982699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00201-06
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados