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Six3 activation of Pax6 expression is essential for mammalian lens induction and specification
The homeobox gene Six3 regulates forebrain development. Here we show that Six3 is also crucial for lens formation. Conditional deletion of mouse Six3 in the presumptive lens ectoderm (PLE) disrupted lens formation. In the most severe cases, lens induction and specification were defective, and the le...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636621/ https://ncbi.nlm.nih.gov/pubmed/17066077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601398 |
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