A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

The antitumor effect of doxorubicin (DOX) conjugated to a biodegradable dendrimer was evaluated in mice bearing C-26 colon carcinomas. An asymmetric biodegradable polyester dendrimer containing 8–10 wt % DOX was prepared. The design of the dendrimer carrier optimized blood circulation time through s...

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Main Authors: Lee, Cameron C., Gillies, Elizabeth R., Fox, Megan E., Guillaudeu, Steven J., Fréchet, Jean M. J., Dy, Edward E., Szoka, Francis C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Physical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636509/
https://ncbi.nlm.nih.gov/pubmed/17075050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607705103
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