The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant

Yeast cells expressing the Glu418Lys human topoisomerase I mutant display a camptothecin resistance that slowly decreases as a function of time. Molecular characterization of the single steps of the catalytic cycle of the purified mutant indicates that it has a relaxation activity identical to the w...

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Hlavní autoři: Fiorani, Paola, Chillemi, Giovanni, Losasso, Carmen, Castelli, Silvia, Desideri, Alessandro
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2006
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636438/
https://ncbi.nlm.nih.gov/pubmed/16990249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl670
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