Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase.

A new drug screening method was devised utilizing Trypanosoma cruzi cells that express the Escherichia coli beta-galactosidase gene. Transfected parasites catalyze a colorimetric reaction with chlorophenol red beta-D-galactopyranoside as substrate. Parasite growth in the presence of drugs in microti...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Buckner, F S, Verlinde, C L, La Flamme, A C, Van Voorhis, W C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163582/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8913471/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.11.2592
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