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B cell–specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5
Immunoglobulin heavy chain rearrangement (V(H)-to-DJ(H)) occurs only in B cells, suggesting it is inhibited in other lineages. Here we found that in the mouse V(H) locus, methylation of lysine 9 on histone H3 (H3-K9), a mark of inactive chromatin, was present in non–B lineage cells but was absent in...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1635547/ https://ncbi.nlm.nih.gov/pubmed/15258579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1099 |
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