B cell–specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5

Immunoglobulin heavy chain rearrangement (V(H)-to-DJ(H)) occurs only in B cells, suggesting it is inhibited in other lineages. Here we found that in the mouse V(H) locus, methylation of lysine 9 on histone H3 (H3-K9), a mark of inactive chromatin, was present in non–B lineage cells but was absent in...

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Autors principals: Johnson, Kristen, Pflugh, David L, Yu, Duonan, Hesslein, David G T, Lin, Kuo-I, Bothwell, Alfred L M, Thomas-Tikhonenko, Andrei, Schatz, David G, Calame, Kathryn
Format: Artigo
Idioma:Inglês
Publicat: 2004
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635547/
https://ncbi.nlm.nih.gov/pubmed/15258579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni1099
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