The Role of DNA Double-Strand Breaks in Spontaneous Homologous Recombination in S. cerevisiae

Homologous recombination (HR) is a source of genomic instability and the loss of heterozygosity in mitotic cells. Since these events pose a severe health risk, it is important to understand the molecular events that cause spontaneous HR. In eukaryotes, high levels of HR are a normal feature of meios...

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Main Authors: Lettier, Gaëlle, Feng, Qi, de Mayolo, Adriana Antúnez, Erdeniz, Naz, Reid, Robert J. D, Lisby, Michael, Mortensen, Uffe H, Rothstein, Rodney
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635536/
https://ncbi.nlm.nih.gov/pubmed/17096599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020194
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