Implication of Ile-69 and Thr-182 residues in kinetic characteristics of IRT-3 (TEM-32) beta-lactamase.

The substitution of a methionine for an isoleucine at position 69 (Met69Ile), which causes inhibitor resistance to TEM-type beta-lactamases (IRT-3 and IRT-I69), altered the positions of the Asn-170 and Glu-166 side chains as well as the position of the catalytic water molecule. A novel hydrogen bond...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Farzaneh, S, Chaibi, E B, Peduzzi, J, Barthelemy, M, Labia, R, Blazquez, J, Baquero, F
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163551/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8891161/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2434
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