Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.

Aminoquinoline resistance correlates with lipid solubility at pH 7.2. Consequently, the in vivo dealkylation of amodiaquine, to the less lipid-soluble desethylamodiaquine, is a likely contributor to therapeutic failure in vivo. Therefore, 4-aminoquinoline drugs with lipid solubilities similar to tha...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Hawley, S R, Bray, P G, O'Neill, P M, Naisbitt, D J, Park, B K, Ward, S A
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163532/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8891142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2345
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