Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.
Aminoquinoline resistance correlates with lipid solubility at pH 7.2. Consequently, the in vivo dealkylation of amodiaquine, to the less lipid-soluble desethylamodiaquine, is a likely contributor to therapeutic failure in vivo. Therefore, 4-aminoquinoline drugs with lipid solubilities similar to tha...
שמור ב:
| הוצא לאור ב: | Antimicrob Agents Chemother |
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| Principais autores: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Microbiology (ASM)
1996
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163532/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8891142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2345 |
| תגים: |
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