Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications

Proliferating cell nuclear antigen (PCNA) acts as a biologically essential processivity factor that encircles DNA and provides binding sites for polymerase, flap endonuclease-1 (FEN-1) and ligase during DNA replication and repair. We have computationally characterized the interactions of human and A...

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Bibliographic Details
Main Authors: Ivanov, Ivaylo, Chapados, Brian R., McCammon, J. Andrew, Tainer, John A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2006
Subjects:
Computational Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635319/
https://ncbi.nlm.nih.gov/pubmed/17071716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl744
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