Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells

RNA interference and the microRNA (miRNA) pathway can induce sequence-specific mRNA degradation and/or translational repression. The human genome encodes hundreds of miRNAs that can post-transcriptionally repress thousands of genes. Using reporter constructs, we observed that degradation of mRNAs be...

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Bibliografske podrobnosti
Main Authors: Schmitter, Daniela, Filkowski, Jody, Sewer, Alain, Pillai, Ramesh S., Oakeley, Edward J., Zavolan, Mihaela, Svoboda, Petr, Filipowicz, Witold
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2006
Teme:
Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635286/
https://ncbi.nlm.nih.gov/pubmed/16971455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl646
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