Pharmacokinetic Considerations and Efficacy of Levofloxacin in an Inhalational Anthrax (Postexposure) Rhesus Monkey Model

Because the treatment of inhalational anthrax cannot be studied in human clinical trials, it is necessary to conduct efficacy studies using a rhesus monkey model. However, the half-life of levofloxacin was approximately three times shorter in rhesus monkeys than in humans. Computer simulations to ma...

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Bibliografske podrobnosti
Main Authors: Kao, L. Mark , Bush, Karen, Barnewall, Roy, Estep, James, Thalacker, Frederic W., Olson, Pamela H. , Drusano, George L., Minton, Neil, Chien, Shuchean, Hemeryck, Alex, Kelley, Michael F.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635218/
https://ncbi.nlm.nih.gov/pubmed/17065619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00090-06
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