Pharmacokinetic Considerations and Efficacy of Levofloxacin in an Inhalational Anthrax (Postexposure) Rhesus Monkey Model

Because the treatment of inhalational anthrax cannot be studied in human clinical trials, it is necessary to conduct efficacy studies using a rhesus monkey model. However, the half-life of levofloxacin was approximately three times shorter in rhesus monkeys than in humans. Computer simulations to ma...

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Bibliografiske detaljer
Main Authors: Kao, L. Mark , Bush, Karen, Barnewall, Roy, Estep, James, Thalacker, Frederic W., Olson, Pamela H. , Drusano, George L., Minton, Neil, Chien, Shuchean, Hemeryck, Alex, Kelley, Michael F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635218/
https://ncbi.nlm.nih.gov/pubmed/17065619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00090-06
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