Molecular Basis for Enhanced Activity of Posaconazole against Absidia corymbifera and Rhizopus oryzae

Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae, than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased...

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Autors principals: Chau, Andrew S., Chen, Guodong, McNicholas, Paul M., Mann, Paul A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635193/
https://ncbi.nlm.nih.gov/pubmed/16966400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00747-06
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