Emergence of a Novel Lamivudine-Resistant Hepatitis B Virus Variant with a Substitution Outside the YMDD Motif

Lamivudine is a major drug approved for treatment of chronic hepatitis B virus (HBV) infection. Emergence of drug-resistant mutants with amino acid substitutions in the YMDD motif is a well-documented problem during long-term lamivudine therapy. Here we report a novel lamivudine-resistant strain of...

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Bibliographische Detailangaben
Hauptverfasser: Yatsuji, Hiromi, Noguchi, Chiemi, Hiraga, Nobuhiko, Mori, Nami, Tsuge, Masataka, Imamura, Michio , Takahashi, Shoichi, Iwao, Eiji, Fujimoto, Yoshifumi, Ochi, Hidenori, Abe, Hiromi, Maekawa, Toshiro, Tateno, Chise, Yoshizato, Katsutoshi, Suzuki, Fumitaka, Kumada, Hiromitsu, Chayama, Kazuaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635170/
https://ncbi.nlm.nih.gov/pubmed/16982790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00239-06
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