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Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis

Loss of Treg function appears to be a critical factor in the pathogenesis of human autoimmune diseases. Attention has focused on defects of CD4(+)CD25(high) Tregs, and techniques have been developed to determine their function. In contrast, the role of Tr1 regulatory T cells, which secrete the antii...

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Hlavní autoři: Astier, Anne L., Meiffren, Gregory, Freeman, Samuel, Hafler, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635165/
https://ncbi.nlm.nih.gov/pubmed/17099776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29251
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