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Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy

For paramyxoviruses, two viral glycoproteins are key to the entry process: an attachment protein (HN, H, or G) and the fusion protein (F). The F protein folds to a metastable state that can be triggered to undergo large conformational rearrangements to a fusogenic intermediate and a more stable post...

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Detalhes bibliográficos
Main Authors: Connolly, Sarah A., Leser, George P., Yin, Hsien-Shen, Jardetzky, Theodore S., Lamb, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635158/
https://ncbi.nlm.nih.gov/pubmed/17093041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608678103
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