Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and...

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Detaylı Bibliyografya
Asıl Yazarlar: Thijssen, Victor L. J. L., Postel, Ruben, Brandwijk, Ricardo J. M. G. E., Dings, Ruud P. M., Nesmelova, Irina, Satijn, Sietske, Verhofstad, Nicole, Nakabeppu, Yusaku, Baum, Linda G., Bakkers, Jeroen, Mayo, Kevin H., Poirier, Françoise, Griffioen, Arjan W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635112/
https://ncbi.nlm.nih.gov/pubmed/17043243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603883103
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