Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and...

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Detalhes bibliográficos
Main Authors: Thijssen, Victor L. J. L., Postel, Ruben, Brandwijk, Ricardo J. M. G. E., Dings, Ruud P. M., Nesmelova, Irina, Satijn, Sietske, Verhofstad, Nicole, Nakabeppu, Yusaku, Baum, Linda G., Bakkers, Jeroen, Mayo, Kevin H., Poirier, Françoise, Griffioen, Arjan W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635112/
https://ncbi.nlm.nih.gov/pubmed/17043243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603883103
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