Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and...

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Main Authors: Thijssen, Victor L. J. L., Postel, Ruben, Brandwijk, Ricardo J. M. G. E., Dings, Ruud P. M., Nesmelova, Irina, Satijn, Sietske, Verhofstad, Nicole, Nakabeppu, Yusaku, Baum, Linda G., Bakkers, Jeroen, Mayo, Kevin H., Poirier, Françoise, Griffioen, Arjan W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635112/
https://ncbi.nlm.nih.gov/pubmed/17043243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603883103
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