Local Delivery of a Synthetic Endostatin Fragment for the Treatment of Experimental Gliomas

OBJECTIVE: Endostatin is an anti-angiogenic agent that blocks matrix-metalloproteinase-2 and inhibits endothelial cell proliferation. Currently, endostatin is available through recombinant technology, which limits its broader use. In this study, a synthetic endostatin fragment (EF) was analyzed to d...

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Main Authors: Pradilla, Gustavo, Legnani, Federico G., Petrangolini, Giovanna, Francescato, Pierangelo, Chillemi, Francesco, Tyler, Betty M., Gaini, Sergio M., Brem, Henry, Olivi, Alessandro, DiMeco, Francesco
Format: Artigo
Language:Inglês
Published: 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635009/
https://ncbi.nlm.nih.gov/pubmed/16284573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/01.NEU.0000180059.33665.c1
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