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Lactacystin Exhibits Potent Anti-Tumor Activity in an Animal Model of Malignant Glioma when Administered via Controlled-Release Polymers
Lactacystin, a proteasome-inhibitor, has been shown to induce apoptosis of experimental gliomas in vitro. However, its systemic toxicity prevents further clinical use. To circumvent this problem, lactacystin can be delivered intratumorally. We tested the efficacy of lactacystin incorporated into con...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1635004/ https://ncbi.nlm.nih.gov/pubmed/16609837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-005-6937-3 |
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