Ablation of PGC-1β Results in Defective Mitochondrial Activity, Thermogenesis, Hepatic Function, and Cardiac Performance

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) has been implicated in important metabolic processes. A mouse lacking PGC-1β (PGC1βKO) was generated and phenotyped using physiological, molecular, and bioinformatic approaches. PGC1βKO mice are...

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Autors principals: Lelliott, Christopher J, Medina-Gomez, Gema, Petrovic, Natasa, Kis, Adrienn, Feldmann, Helena M, Bjursell, Mikael, Parker, Nadeene, Curtis, Keira, Campbell, Mark, Hu, Ping, Zhang, Dongfang, Litwin, Sheldon E, Zaha, Vlad G, Fountain, Kimberly T, Boudina, Sihem, Jimenez-Linan, Mercedes, Blount, Margaret, Lopez, Miguel, Meirhaeghe, Aline, Bohlooly-Y, Mohammad, Storlien, Leonard, Strömstedt, Maria, Snaith, Michael, Orešič, Matej, Abel, E. Dale, Cannon, Barbara, Vidal-Puig, Antonio
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1634886/
https://ncbi.nlm.nih.gov/pubmed/17090215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040369
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