Cellular uptake and biological effects of antisense oligodeoxynucleotide analogs targeted to herpes simplex virus.

In this study, we synthesized antisense oligodeoxynucleotides (ODNs) with phosphodiester, phosphorothioate (S-ODNs), or methylphosphonate linkages complementary to the splicing acceptor site of immediate-early pre-mRNA 5 of herpes simplex virus type 1 (HSV-1). The antiviral activity of each analog o...

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Autores principales: Shoji, Y, Shimada, J, Mizushima, Y, Iwasawa, A, Nakamura, Y, Inouye, K, Azuma, T, Sakurai, M, Nishimura, T
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC163393/
https://ncbi.nlm.nih.gov/pubmed/8807060
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