Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase from Escherichia coli.

Using a continuous fluorescence-based enzyme assay, we have characterized the antibacterial agents tumicamycin and liposidomycin B as inhibitors of solubilized Escherichia coli phospho-N-acetylmuramyl-pentapeptide translocase. Tunicamycin exhibited reversible inhibition (Ki = 0.55 +/- 0.1 microM) wh...

Full description

Saved in:
Bibliographic Details
Main Authors: Brandish, P E, Kimura, K I, Inukai, M, Southgate, R, Lonsdale, J T, Bugg, T D
Format: Artigo
Language:Inglês
Published: 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC163387/
https://ncbi.nlm.nih.gov/pubmed/8807054
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items