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Antimalarial and toxic effects of the acyclic nucleoside phosphonate (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine in Plasmodium berghei-infected mice.

Plasmodium berghei-infected mice died with low levels of parasitemia after repeated intraperitoneal administration (five times at 15 mg kg of body weight-1 every other day) of the in vitro active antimalarial acyclic nucleoside phosphonate (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMP...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Smeijsters, L J, Nieuwenhuijs, H, Hermsen, R C, Dorrestein, G M, Franssen, F F, Overdulve, J P
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163377/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8807044/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.7.1584
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