Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA.

Pyrazinamide (PZA) is one of the three most important drugs for treatment of Mycobacterium tuberculosis infections. The antibacterial activity of PZA requires a bacterial enzyme, pyrazinamidase (PZAase), which hydrolyzes PZA to form pyrazinoic acid and ammonia. Most PZA-resistant clinical M. tubercu...

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Bibliografiska uppgifter
Huvudupphovsmän: Frothingham, R, Meeker-O'Connell, W A, Talbot, E A, George, J W, Kreuzer, K N
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1996
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC163344/
https://ncbi.nlm.nih.gov/pubmed/8726014
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